Mendelian randomisation with coarsened exposures
نویسندگان
چکیده
منابع مشابه
Mendelian Randomisation: A Minireview
, © Wells This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. Mendelian randomisation is a technique which, fuelled by the results of GWA studies, can be used to determine causal relationships between in...
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To infer the causal association between childhood BMI and age at menarche, we performed a mendelian randomisation analysis using twelve established "BMI-increasing" genetic variants as an instrumental variable (IV) for higher BMI. In 8,156 women of European descent from the EPIC-Norfolk cohort, height was measured at age 39-77 years; age at menarche was self-recalled, as was body weight at age ...
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The notion of risk is central to epidemiological research, both in its original context of studying conditions thought to be caused by a particular factor and, more broadly, in predicting the probability of a condition for prognostic purposes. For prognostic research, all factors associated with the outcome are of interest, whether they are causal or not. In aetiological research, on the other ...
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OBJECTIVE To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables. SETTING International Genomics of Alzheimer's Project. PARTICIPANT...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2021
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.22376